Sympatholytic antihypertensive drug

2008

Chronic high blood pressure is dangerous for the body and has to be treated. If hypertension is left untreated for a long time the patient is in high risk of either a hypertensive urgency with severely elevated bloodpressure without end-organ damage. Or a hypertensive emergency in which target organ damage will occur, e.g. hypertensive encephalopathy, preeclampsia and eclampsia, acute left ventricular failure with pulmonary edema, myocardial ischemia, acute aortic dissection, and renal failure. Damage is rapidly progressive and often fatal. In both medically severe conditions a fast-acting hypotensive drug is needed.

Showing the mode of action and the effects of an α1-adrenergic receptor antagonist, α2-adrenergic receptor agonist, and 5-HT1A receptor agonist